locus

BSU25130

BSU_25130

geneLength

891

894

outlinks

bsu

BSU25130

BSU_25130

Gene

Coordinates

2,593,281 → 2,594,174

2,593,281 2,594,174

Gene

Phenotypes of a mutant

an ''[[gene|exoR]] [[gene|nfo]]'' double mutant is impaired in germination and spore outgrowth due to the accumulation of DNA lesions, this can be rescued by inactivation of ''[[gene|disA]]'' [Pubmed|24244006]

an ''[[gene|exoR]] [[gene|nfo]]'' double mutant is sensitive to radiation [Pubmed|24123749]

an ''[[gene|exoR]] [[gene|nfo]]'' double mutant is impaired in germination and spore outgrowth due to the accumulation of DNA lesions, this can be rescued by inactivation of ''[[gene|disA]]'' [Pubmed|24244006]

an ''[[gene|exoR]] [[gene|nfo]]'' double mutant is sensitive to radiation [Pubmed|24123749]

sensitive to blue light-induced DNA damage [pubmed|30054368]

reduced resistance towards electron beams [pubmed|31948638]

The protein

Catalyzed reaction/ biological activity

Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products (according to Swiss-Prot)

Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products (according to UniProt)

The protein

Protein family

AP endonuclease 2 family (according to Swiss-Prot)

AP endonuclease 2 family (single member, according to UniProt)

Biological materials

Mutant

MGNA-C462 (yqfS::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2460 NBRP B. subtilis, Japan]

available in [[Mario Pedraza-Reyes]]' lab

GP899 (Δ''nfo''::''kan'') and GP1502 (Δ''nfo''::''cat''), available in [SW|Jörg Stülke]'s lab

MGNA-C462 (yqfS::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2460 NBRP B. subtilis, Japan]

available in [SW|Mario Pedraza-Reyes]'s lab

GP899 (Δ''nfo''::''kan'') and GP1502 (''nfo''::''cat''), available in [SW|Jörg Stülke]'s lab [pubmed|22178973]

BKE25130 (Δ[[gene|nfo]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE25130 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GCCTATTCTCAGCAACAGGT, downstream forward: _UP4_TAAAAAATGGGGGATAACAC

BKK25130 (Δ[[gene|nfo]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK25130 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GCCTATTCTCAGCAACAGGT, downstream forward: _UP4_TAAAAAATGGGGGATAACAC

References

Original publications

24244006, 18203828, 16237020, 12949090, 19930460, 12486072, 21441501, 24123749, 24123749, 24914186, 21358045

24244006, 18203828, 16237020, 12949090, 19930460, 12486072, 21441501, 24123749, 24914186, 21358045, 30054368, 31948638

The protein

Paralogous protein(s)

[[this]]